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cx43 gap junction blocker (MedChemExpress)

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MedChemExpress cx43 gap junction blocker

Reduction of AST <t>PGC‐1α–CX43</t> axis in SPS mice was responsible for the enhanced fear retrieval. (A) Experimental steps of FACS ( n = 3/group); (B) gate strategy and sorting results; (C) representative bands and quantitative data of PGC‐1α and NRF1 proteins; (D) representative bands and quantitative data of hippocampal <t>CX43</t> protein in the control group and on Days 1, 7, and 14 after SPS modeling; (E) flowchart of the experiment ( n = 6/group); (F and G) freezing time of Con+CSF and Con+GAP27 group mice in the contextual fear test (F) and the cued fear test (G); (H) ELISA for detecting the ATP levels in the hippocampal tissues of the mice in the Con+CSF and Con+GAP27 groups; (I) ELISA for detecting the ATP levels in the hippocampal tissues of the mice in the control and SPS groups. Data are presented as mean and SEM. * p < 0.05, *** p < 0.001 between groups ( t ‐test or Tukey test).

Cx43 Gap Junction Blocker, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 17 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cx43+gap+junction+blocker/pmc12966805-222-3-8?v=MedChemExpress
Average 94 stars, based on 17 article reviews

cx43 gap junction blocker - by Bioz Stars, 2026-08

94/100 stars

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1) Product Images from "Peroxisome Proliferator‑Activated Receptor Gamma Coactivator‑1α Deficiency in Hippocampal Astrocytes Underlies Enhanced Fear Memory Retrieval in Male Posttraumatic Stress Disorder Model Mice"

Article Title: Peroxisome Proliferator‑Activated Receptor Gamma Coactivator‑1α Deficiency in Hippocampal Astrocytes Underlies Enhanced Fear Memory Retrieval in Male Posttraumatic Stress Disorder Model Mice

Journal: MedComm

doi: 10.1002/mco2.70671

Reduction of AST PGC‐1α–CX43 axis in SPS mice was responsible for the enhanced fear retrieval. (A) Experimental steps of FACS ( n = 3/group); (B) gate strategy and sorting results; (C) representative bands and quantitative data of PGC‐1α and NRF1 proteins; (D) representative bands and quantitative data of hippocampal CX43 protein in the control group and on Days 1, 7, and 14 after SPS modeling; (E) flowchart of the experiment ( n = 6/group); (F and G) freezing time of Con+CSF and Con+GAP27 group mice in the contextual fear test (F) and the cued fear test (G); (H) ELISA for detecting the ATP levels in the hippocampal tissues of the mice in the Con+CSF and Con+GAP27 groups; (I) ELISA for detecting the ATP levels in the hippocampal tissues of the mice in the control and SPS groups. Data are presented as mean and SEM. * p < 0.05, *** p < 0.001 between groups ( t ‐test or Tukey test).

Figure Legend Snippet: Reduction of AST PGC‐1α–CX43 axis in SPS mice was responsible for the enhanced fear retrieval. (A) Experimental steps of FACS ( n = 3/group); (B) gate strategy and sorting results; (C) representative bands and quantitative data of PGC‐1α and NRF1 proteins; (D) representative bands and quantitative data of hippocampal CX43 protein in the control group and on Days 1, 7, and 14 after SPS modeling; (E) flowchart of the experiment ( n = 6/group); (F and G) freezing time of Con+CSF and Con+GAP27 group mice in the contextual fear test (F) and the cued fear test (G); (H) ELISA for detecting the ATP levels in the hippocampal tissues of the mice in the Con+CSF and Con+GAP27 groups; (I) ELISA for detecting the ATP levels in the hippocampal tissues of the mice in the control and SPS groups. Data are presented as mean and SEM. * p < 0.05, *** p < 0.001 between groups ( t ‐test or Tukey test).

Techniques Used: Control, Enzyme-linked Immunosorbent Assay

AST PGC‐1α knockdown enhanced fear memory and anxiety‐like behaviors and impaired AST structure. (A) Flowchart of the experiment ( n = 9/group); (B) representative images of virus‐labeled astrocytes; (C) representative bands and quantitative data of PGC‐1α and CX43; (D) freezing of mice in the contextual fear test; (E) freezing of mice in the cued fear test; (F) the percentage of time that mice spent exploring the open arm in the elevated maze test out of the total time; (G and H) the total distance and representative traces of the open field test; (I and J) the results and representative images of the Sholl analysis of astrocytes. The data are presented as mean ± standard error ( n = 3/group). (K) Representative image of S100A10 immunofluorescence staining (scale bar: 50 µm); (L) the percentage of colabeling of S100A10 and PGC‐1α ( n = 3/group). Data are presented as mean and SEM. *p < 0.05, **p < 0.01, ***p < 0.001 between groups ( t ‐test).

Figure Legend Snippet: AST PGC‐1α knockdown enhanced fear memory and anxiety‐like behaviors and impaired AST structure. (A) Flowchart of the experiment ( n = 9/group); (B) representative images of virus‐labeled astrocytes; (C) representative bands and quantitative data of PGC‐1α and CX43; (D) freezing of mice in the contextual fear test; (E) freezing of mice in the cued fear test; (F) the percentage of time that mice spent exploring the open arm in the elevated maze test out of the total time; (G and H) the total distance and representative traces of the open field test; (I and J) the results and representative images of the Sholl analysis of astrocytes. The data are presented as mean ± standard error ( n = 3/group). (K) Representative image of S100A10 immunofluorescence staining (scale bar: 50 µm); (L) the percentage of colabeling of S100A10 and PGC‐1α ( n = 3/group). Data are presented as mean and SEM. *p < 0.05, **p < 0.01, ***p < 0.001 between groups ( t ‐test).

Techniques Used: Knockdown, Virus, Labeling, Immunofluorescence, Staining

Activation of hippocampal AST or PGC‐1α reduced fear memory retrieval in SPS mice. (A) Flowchart of experiment 5 ( n = 7/group); (B) representative image of immunofluorescence of hM3Dq‐labeled AST; (C) freezing time of mice in the contextual fear test; (D) freezing time of mice in the cued fear test; (E) percentage of time that mice spent exploring the open arm in the elevated maze test out of the total time; (F) flowchart of the experiment 5 ( n = 6/group); (G) freezing time of mice in the contextual fear memory; (H) freezing time of mice in the cued fear memory; (I) percentage of time that mice spent exploring the open arm in the elevated maze test out of the total time; (J and K) representative bands of GFAP (J) and CX43 (K) along with quantitative data; (L) flowchart of the experiment 6 ( n = 7/group); (M) schematic diagram of the hM3Dq–mCherry/AAV5–PGC‐1α viral injection site and colabeling; (N) freezing time of mice in the contextual fear memory; (O) freezing time of mice in the cued fear memory. Data are presented as mean and SEM. * p < 0.05, ** p < 0.01, *** p < 0.001 between groups ( t ‐test or Tukey test).

Figure Legend Snippet: Activation of hippocampal AST or PGC‐1α reduced fear memory retrieval in SPS mice. (A) Flowchart of experiment 5 ( n = 7/group); (B) representative image of immunofluorescence of hM3Dq‐labeled AST; (C) freezing time of mice in the contextual fear test; (D) freezing time of mice in the cued fear test; (E) percentage of time that mice spent exploring the open arm in the elevated maze test out of the total time; (F) flowchart of the experiment 5 ( n = 6/group); (G) freezing time of mice in the contextual fear memory; (H) freezing time of mice in the cued fear memory; (I) percentage of time that mice spent exploring the open arm in the elevated maze test out of the total time; (J and K) representative bands of GFAP (J) and CX43 (K) along with quantitative data; (L) flowchart of the experiment 6 ( n = 7/group); (M) schematic diagram of the hM3Dq–mCherry/AAV5–PGC‐1α viral injection site and colabeling; (N) freezing time of mice in the contextual fear memory; (O) freezing time of mice in the cued fear memory. Data are presented as mean and SEM. * p < 0.05, ** p < 0.01, *** p < 0.001 between groups ( t ‐test or Tukey test).

Techniques Used: Activation Assay, Immunofluorescence, Labeling, Injection

Image Search Results

Journal: MedComm

doi: 10.1002/mco2.70671

Figure Lengend Snippet: Reduction of AST PGC‐1α–CX43 axis in SPS mice was responsible for the enhanced fear retrieval. (A) Experimental steps of FACS ( n = 3/group); (B) gate strategy and sorting results; (C) representative bands and quantitative data of PGC‐1α and NRF1 proteins; (D) representative bands and quantitative data of hippocampal CX43 protein in the control group and on Days 1, 7, and 14 after SPS modeling; (E) flowchart of the experiment ( n = 6/group); (F and G) freezing time of Con+CSF and Con+GAP27 group mice in the contextual fear test (F) and the cued fear test (G); (H) ELISA for detecting the ATP levels in the hippocampal tissues of the mice in the Con+CSF and Con+GAP27 groups; (I) ELISA for detecting the ATP levels in the hippocampal tissues of the mice in the control and SPS groups. Data are presented as mean and SEM. * p < 0.05, *** p < 0.001 between groups ( t ‐test or Tukey test).

Article Snippet: Gap 27, a CX43 gap junction blocker (HY‐P0139; MCE), was intracranially administered at 0.5 μL per side with a concentration of 100 μM [ ].

Techniques: Control, Enzyme-linked Immunosorbent Assay

Journal: MedComm

doi: 10.1002/mco2.70671

Figure Lengend Snippet: AST PGC‐1α knockdown enhanced fear memory and anxiety‐like behaviors and impaired AST structure. (A) Flowchart of the experiment ( n = 9/group); (B) representative images of virus‐labeled astrocytes; (C) representative bands and quantitative data of PGC‐1α and CX43; (D) freezing of mice in the contextual fear test; (E) freezing of mice in the cued fear test; (F) the percentage of time that mice spent exploring the open arm in the elevated maze test out of the total time; (G and H) the total distance and representative traces of the open field test; (I and J) the results and representative images of the Sholl analysis of astrocytes. The data are presented as mean ± standard error ( n = 3/group). (K) Representative image of S100A10 immunofluorescence staining (scale bar: 50 µm); (L) the percentage of colabeling of S100A10 and PGC‐1α ( n = 3/group). Data are presented as mean and SEM. *p < 0.05, **p < 0.01, ***p < 0.001 between groups ( t ‐test).

Article Snippet: Gap 27, a CX43 gap junction blocker (HY‐P0139; MCE), was intracranially administered at 0.5 μL per side with a concentration of 100 μM [ ].

Techniques: Knockdown, Virus, Labeling, Immunofluorescence, Staining

Journal: MedComm

doi: 10.1002/mco2.70671

Figure Lengend Snippet: Activation of hippocampal AST or PGC‐1α reduced fear memory retrieval in SPS mice. (A) Flowchart of experiment 5 ( n = 7/group); (B) representative image of immunofluorescence of hM3Dq‐labeled AST; (C) freezing time of mice in the contextual fear test; (D) freezing time of mice in the cued fear test; (E) percentage of time that mice spent exploring the open arm in the elevated maze test out of the total time; (F) flowchart of the experiment 5 ( n = 6/group); (G) freezing time of mice in the contextual fear memory; (H) freezing time of mice in the cued fear memory; (I) percentage of time that mice spent exploring the open arm in the elevated maze test out of the total time; (J and K) representative bands of GFAP (J) and CX43 (K) along with quantitative data; (L) flowchart of the experiment 6 ( n = 7/group); (M) schematic diagram of the hM3Dq–mCherry/AAV5–PGC‐1α viral injection site and colabeling; (N) freezing time of mice in the contextual fear memory; (O) freezing time of mice in the cued fear memory. Data are presented as mean and SEM. * p < 0.05, ** p < 0.01, *** p < 0.001 between groups ( t ‐test or Tukey test).

Article Snippet: Gap 27, a CX43 gap junction blocker (HY‐P0139; MCE), was intracranially administered at 0.5 μL per side with a concentration of 100 μM [ ].

Techniques: Activation Assay, Immunofluorescence, Labeling, Injection

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Structured Review

Images

1) Product Images from "Peroxisome Proliferator‑Activated Receptor Gamma Coactivator‑1α Deficiency in Hippocampal Astrocytes Underlies Enhanced Fear Memory Retrieval in Male Posttraumatic Stress Disorder Model Mice"

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